The 20th Annual R. Bryan Miller Symposium took place on March 5th and 6th, 2020 on the campus of UC Davis. The speaker lineup was top-notch, including plenary lectures by Bob Bergman (UCB) and Jennifer Doudna (UCB), Keynote lectures by Cynthia Burroughs (Utah) and Eric Anslyn (UT Austin), and many additional lectures from chemists in both academia and the pharmaceutical industry. The student poster session, sponsored by SAC ACS, had a fantastic turnout, featuring new research from undergraduates, graduates students and postdocs from the Sacramento area!